People

Alan Brown

Alan Brown

Principal Investigator

Alan did his Ph.D. at the University of Cambridge with Tom Blundell and was a postdoc for Matt Higgins and Venki Ramakrishnan. He started at HMS in September 2017 and was named a Pew Scholar in 2019.

ORCID iD orcid.org/0000-0002-0021-0476

 

Jacob R. Anderson

Jacob R. Anderson

Ph.D. Candidate

Jacob received his bachelor's degree from the University of Michigan in 2017. He is a Chemical Biology student in Harvard's MD-PhD program. Before graduate school, Jacob worked in Nils Walter's laboratory using TIRF microscopy to measure kinetics of oligonucleotide binding and in Adriaan Bax's laboratory measuring rates of hydrogen exchange of backbone amides in intrinsically disordered proteins. Jacob joined the lab in May 2020. 

ORCID iD orcid.org/0000-0002-1179-717X

Jin Dai

Jin Dai

Post-Doctoral Fellow

Jin Dai joined the lab in August 2021 and was the first member to join from another cilia lab. Jin obtained his B.Sc. from Peking University, Beijing, before moving to the U.S. for a Ph.D. with Dr. Karl Lechtreck. In his research with Karl, Jin studied how axonemal dyneins are transported by intraflagellar transport.

Miao Gui

Miao Gui

Post-Doctoral Fellow

Miao trained at Peking University and Tsinghua University as a joint Ph.D. He then joined the Innovation Center for Structural Biology of Tsinghua University as a postdoc. In China, Miao mainly worked on the virus surface glycoproteins using cryo-EM. Miao joined the lab in January 2019 and was awarded a BCMP-Merck Postdoctoral Fellowship later that year. He studies the mechanoregulation of ciliary motility and recently determined the structure of a radial spoke. Miao also collaborates with the Wagner lab to determine cryo-EM structures of nanodisc-embedded GPCR complexes. Miao is a 2021 Charles A King Trust Postdoctoral Fellow.

ORCID iD orcid.org/0000-0001-9113-8029

Shimi Meleppattu

Shimi Meleppattu

Research associate

Shimi received her Ph.D. degree from the Department of Biotechnology, Pune University, India where she studied stress-induced regulation of protein synthesis in protozoan parasites. As a postdoctoral fellow at Ben-Gurion University, Israel, and later at Harvard Medical School, she worked on the characterization of translational initiation complexes in Leishmania. Shimi joined the lab in 2019 as a Research Associate.

Sandeep Singh

Sandeep Singh

Post-Doctoral Fellow

Sandeep received his Ph.D. degree from IMTECH, India in biochemistry and molecular biology. He studied the nitric oxide evasion strategy of Mycobacterium tuberculosis. Later, he joined Purdue University as a postdoc and worked on transmembrane signaling and the formation of membrane-protein supercomplexes. Sandeep currently works on the structure and function of complexes involved in transporting membrane proteins including the mammalian BBSome

ORCID iD orcid.org/0000-0001-9322-2929

Travis Walton

Travis Walton

Post-Doctoral Fellow

Travis received his PhD from Harvard University in 2019 by uncovering a novel chemical mechanism for nonenzymatic RNA polymerization in the laboratory of Jack W. Szostak. Before his doctoral training, he studied transcriptional regulation during C. elegans development using microscopic and genomic approaches in the laboratory of John I. Murray at the University of Pennsylvania. Travis is continuing his scientific training in the Brown lab with biochemical and structural studies of axonemal dyneins. Travis is a 2019 Helen Hay Whitney Fellow.

ORCID iD orcid.org/0000-0001-6812-1579

Haixia Zhou

Haixia Zhou

Post-Doctoral Fellow

Haixia received her Ph.D. from Tsinghua University in 2019. She worked on isolating and characterizing new monoclonal antibodies against the MERS-CoV infection by combining cryo-EM, X-ray crystallography, and biochemistry. Haixia joined the lab in September 2019 as a joint postdoc with Dr. Johannes Walter. Haixia is a 2021 BCMP-Merck Postdoctoral Fellow.