Molecular Transport in the Cilium

One of our long-term goals is to understand transport mechanisms in the cilium. We are particularly interested in the interplay between microtubules, motor proteins, adaptor complexes and their cargoes, and the role of these processes in signaling pathways. To do this we use a combination of structural, biophysical and biochemical techniques with an emphasis on high-resolution electron microscopy. An example of our recent work in this area is the cryo-EM structure of the mammalian BBSome complex, which transports transmembrane proteins in the cilium.