News

Our new collaborative paper on the structure of radial spokes and associated complexes has been published in Nat. Struct. Mol. Biol. This was a huge effort led by Miao Gui who continued a project started by Adrian Koh when he was a postdoc in the lab. We're especially indebted to Erica Sze-Tu, a co-op undergraduate, who did a tremendous job perfecting flagella purification. The paper can be read for free here: https://rdcu.be/ccbVa.

Today we welcome Lauren to the lab for her first in-person rotation since arriving at Harvard from the University of Minnesota. Lauren will be working closely with Haixia Zhou and hopes to learn some EM.

Science resumes!

Jacob Anderson becomes the lab's very first Ph.D. student. He will be studying the structural basis of ciliopathies. 

The Brown lab will be shut down for at least 6 weeks in response to COVID-19.

SBGrid profiles the Brown lab in their latest Member Tale

Thanks to Narcis Petriman and Esben Lorentzen for profiling Sandeep's recent BBSome paper in an Insight Article for eLife. 

HMS has put together a video showcasing the use of cryo-EM in biomedical research. Watch it here.

Thanks to Alexey Amunts for recommending our recent BBSome paper on F1000.

Sandeep's paper is now published in eLife.

Matthew has joined the lab for 6 months as part of his undergraduate course at Northeastern University.

Today was the last day of Josie's time with us in the lab. She now plans to retreat to the wilderness of Vermont to write up her master's thesis.

Today we say goodbye to Shahad Taqi who has been in the lab for 6 months as part of her bachelor's program at Northeastern Univerisity. We wish Shahad all the best for the future.

Sandeep's paper on the structure of the mammalian native BBSome is now online as a preprint.

Our latest research has been profiled on the HMS website and recommended on F1000.

Our latest paper on the structure of native doublet microtubules from cilia has just been published in Cell. This was a wonderful collaboration with Rui Zhang and Susan Dutcher. Please check out the video abstract on YouTube, which was made for us by Veronica Falconieri.

The lab is delighted to welcome Haixia Zhou as a new postdoctoral fellow from Prof. Xinquan Wang's lab at Tsinghua University. 

Hao Wu joins the lab after a productive time as a grad student at Tsinghua University working on chromatin remodelers. He will be applying his cryo-EM skills to understand the machinery that underpins cilia function.

A big congratulations to Miao Gui, who was today awarded a Merck-BCMP Postdoctoral Fellowship. A very well deserved achievement. 

Today we say goodbye to Erica who returns to continue her degree at Northeastern University. Erica has had a big impact on the lab and will be missed by everyone.

We're very pleased that the Pew Charitable Trust has agreed to fund our research into the formation of cilium-dependent signaling pathways.

Josephine Botsch has joined the lab for 6 months from the University of Tuebingen, Germany for her master's thesis. Josie is familiar with using X-ray crystallography for protein structure elucidation and is now excited to learn more about cryo-EM.

We are delighted to welcome Travis Walton to the lab. Travis joins from Jack Szostak's lab at MGH, where he uncovered a novel chemical mechanism for nonenzymatic RNA polymerization. 

Today we say a sad goodbye to Adrian, who leaves for a great opportunity to work on developing the next generation of electron microscopes at Thermo Fisher. We wish him all the best. 

Our lab welcomes Shimi, who joins as a research associate.

A collaborative effort examining the evolution of the mitochondrial ribosome was published today in Molecular Biology & Evolution. The paper also made the cover with some beautiful artwork by Beata Mierzwa. 

Today we say farewell to Joshua David. Josh was the first member of the group and was instrumental in establishing the lab. We wish him the best of luck as he joins the Schwartz lab at MIT.

Delighted that Miao Gui has joined our lab from Tsinghua University where he studied viral surface proteins by cryo-EM.

Erica Sze-Tu joins the lab for 6 months from Northeastern Univerisity.  

Our News & Views piece on MicroED has been published in Nature. 

Sad to say goodbye to Griffin Rademacher, who returns to Northeastern University. During his time in the lab, Griffin made huge contributions to both wet and dry projects and will be sorely missed. We wish him all the best. 

Our paper with the Shao lab has been published in eLife. 

The lab is delighted that the IRRF has agreed to continue to fund our research for another year. We appreciate the continued support. 

Somewhat unbelievably the lab has now been functional for 1 year! 

Delighted that Griffin Rademacher has joined the lab for 6 months as part of his undergraduate course at Northeastern University. 

Check out our review on ribosomes and cryo-EM, written with Sichen Shao. 

The lab relocates from our shared space with Karen Adelman and Steve Blacklow to our newly renovated space in the C building. 

We're looking to hire a membrane-protein specialist. More details here. 

The lab renovations are gathering pace. See the photos.

Adrian Koh joins the lab from Bob Robinson's group at the Institute of Molecular and Cell Biology, Singapore. 

We're pleased that the E. Matilda Ziegler Foundation for the Blind, Inc. has agreed to fund our research for the next 3 years. 

Sandeep Singh joins the lab from William Cramer's group at Purdue University. 

The lab officially opens. Time to do some science. 

Josh David starts in the lab as a research assistant.

Val Leifer has joined the lab for the summer!

The lab seeks its first research assistant

https://hms.harvard.edu/news/future-molecular-visualization